N-phenylacetyl-L-prolylglycine Ethyl Ester, also known as Noopept, is a touted to be a nootropic that may alleviate cognitive decline.
Noopepet is anxiolytic and mildly psychostimulatory.
It is said that Noopept is 1000 times as potent as Piracetam, although this is a generalization.
Noopept has a molecular structure that is a dipeptide conjugate of Piracetam.
Noopept can be absorbed through the gastrointestinal tract, and is said that it can easily cross the blood brain barrier.
A study has noted that noopept seems to have an anti-amnesiac effect.
Noopept seems to increase Neural Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF) concentrations in the hippocampus.
Noopept, in vitro, seems to have a cholinosensitizing effect; I understand that neurons become more sensitive to acetylcholine.
Noopept is observed to help rats overcome the status of learned helplessness.
Noopept seems to cause longer fibril formation of brain neurons.
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It is 10000% about dosage. Play around with your dose and see what works.
I went from the “recommended” 4.8g twice/day of piracetam to 1.2g twice/day and it’s far more powerful with no brain fog.
The fog is caused by too much.
I believe the reason that racetams are so variant is in the differences in people’s diet. I eat lots of turkey and 4+ eggs a day so I’m getting huge amounts of choline. My guess is with such high levels of natural acetylcholine, im prone to being overstimulated when piracetam makes me use more acteylcholine.
I would guess the average persons diet has nearly no choline and thus they need much more piracetam and potentially supplements. [Source]
Does Noopept Require Choline Supplementation?
If you are cholinergically dominant, no.
If you are cholinergically recessive, you’ll do better by stacking your racetams with a cholinergic adjunct. [Source]
How Does Noopept Work?
Noopept enhances the binding activity of Hypoxia Inducible Factor 1 — HIF-1. This is like telling your brain that it doesn’t have enough oxygen and so it has to compensate. At low doses, your brain goes into overdrive to adjust for the “lack” of oxygen, but at higher doses it shuts some operation down to protect against potential death (note, not a danger with noopept, just the mechanism of HIF). Stick to a lower dosage and it’ll work great for you! I’d also recommend tapering off if you take it for an extended period of time; I had shortness of breath for about two months after being on it for three. [Source]
My Thoughts on Noopept
Be careful of using relatively new nootropics. You want to look at not only the studies, but people’s anecdotes about any nootropic, including Noopept. Browsing through forums, it seems that although some people say they benefit from Noopept, others seems to become more suicidal or depressed.
Noopept is an interesting substance. I do believe that it causes neurogenesis in the brain, which parts exactly I have to check. But you have to wonder, how does noopept stimulate neurogenesis in the brain in the first place? Well, I do believe it is by hormesis that noopept acts on the brain; specifically, and I do have to look for studies, noopept causes mild hypoxia or oxygen deprivation upon the cells of the brain. This, I do believe, isnt’ enough to kill the brain cells outright, but enough oxygen deprivation to bring out an adaptive response from the brain. Which is via neurogenesis. I do also believe that oxygen deprivation may also promote the growth of more blood vessels, as an increase in blood delivery may help compensate for low oxygen levels.
This actually explains why too much noopept can have negative side effects like brain fog. So for those who do use noopept as a brain supplement, do please be careful with the dosage that you take. Indeed, you should treat noopept as a mild poison that is may bring out a beneficial adaption in small amounts, but actually become substantially harmful in bigger amounts. The dose makes the poison, after all.